In this IBM Technote you can find a list of obsolete NOTES.INI entries beginning with Notes/Domino 7.0:

Obsolete as of Notes and Domino 9.0.1

ACTIVATE_SYMLINKS
CoreGraphicsText
Debug_LDAP_VPool
DebugMaxRebuildDetect
DebugMaxRebuildWaitSeconds
DEBUG_MOUSEOVER
DEBUG_NSF_SIX_X_CONVERTER
DEBUG_NSF_DISABLE_SIX_X_CONVERTER
DEBUG_QOSTEST_BREAK
DEBUG_SERVER_TIMESYNC
DisplayBidiRun
EnablePNGImageResources
ENV_WMCSELECTION_MAXDOCUMENTS
GlobalIME
HTTPPreserveDecodedBackSlash
NET_ENABLE_CLOSE_SESSION_LOOP_CNT_OPTIMIZATION
NOWORKSPACE
PROFILE_FILENAME
QOS_PIPENAME
SERVER_CLOCK_USER
SERVER_DISABLE_TIMESYNC
STPROPSINI[i]
USERAEL


Obsolete variables as of Notes/Domino 8.0.1

ABSort
CALLWS_DUMPHEAP
DEBUG_CA_SERVER
DEBUG_CHECK_ABSTRACT_LENGTH
DEBUG_LS_MEMORY_DUMP
DEBUG_LS_MEMORY_DUMP_OUTFILE
DEBUG_SIMULATE_UNDO_LEAK
ENABLE_ON_DEMAND_COLLATIONS
EnableRTFMergedCells
WSINVOKE_DEBUG


Obsolete variables as of Notes/Domino 8.0

ADMINUSEPROCESSES
BypassNewTotaling
CLUSTER_NAME_CACHE_SIZE
DEBUG_CONSOLETOSCRAP
DEBUG_DB2_QV_ENABLE_HTTP
DEBUG_DISABLE_JIT_SUPPORT
DEBUG_DISABLE_LARGE_FILE_SUPPORT
DEBUG_ENABLE_ODS42
DEBUG_LOGGER_BUF_FULL_MIN_WAIT
DEBUG_NAMELOOKUP_MISSES
DEBUG_NAMELOOKUP_NOHITS_NOERRORS
DEBUG_NLCGTRACE_TEARDOWN
DEBUG_NONQUINCY_DEBUGGER
DEBUG_SCR_ENABLED
DEBUG_SECURE_ALLOW_2048
DEBUGGING_NLMS
DEDICATED
DONT_CACHE_MONITOR_FORMULAS
DWSAddinMaxThreads
EVENT_SETUP_LEVEL_CLEAN_MESSAGES
FT_SUMM_DEFAULT_LANGUAGE
FT_SUMMARY_SIZE
HTTPDomWSForceFromValue
HTTPNoDomWSAppSpace
LSMODULE_TRACE
MACR6StatusBar
MAPI_602PSTFILE
MCC_DefaultLang
MEMORY_LOW_CUSHION
POLICY_USE_POLLASTMOD
PREEMPTIONTIMER
SEG_PER_FIXED_ALLOC
ServerRequiredFileHandles
SESSIONKEY_CHECK_FILE
SKIP_FIXUP
WINCON_GEOMETRY


Obsolete NOTES.INI variables starting w/ 7.0 

The NOTES.INI variables listed below have been made obsolete; either because UI settings exist to enable the functionality or because the functionality is longer required:

LDAPAddress
   In Domino 5.0.1a and subsequent releases, including the Lotus Domino 6
   release and later, the LDAPAddress NOTES.INI variable is ignored. For
   Domino R5 servers and later, bind a Notes TCP port to a specific address, 
   and then have the LDAP service use the Notes port.

namelookup_trust_dircat
   Functionality enabled by the Directory Information setting “Trust the server 
   based condensed directory catalog for authentication with internet 
   protocols” in the Server document of the Domino Directory server.

NWNDSPASSWORD
   IPX/SPX is not supported as of Domino 7.0

NWNDSUSERID
   IPX/SPX is not supported as of Domino 7.0

Shared_Mail

WebAuth_AD_Group
   Functionality enabled by the Active Directory search filter option, which 
   allows for searches of Active Directory groups

iNotes_WA_Chat
   Functionality enabled by the Domino Web Access Instant Messaging setting 
   “Instant Messaging features” in the Configuration Settings document of the 
   Domino Directory server.

iNotes_WA_LiveNames
   Functionality enabled by the Domino Web Access Instant Messaging setting 
   “Online awareness” in the Configuration Settings document of the Domino 
   Directory server.

iNotes_WA_NoLocalArchive
   Functionality now enabled by the Domino Web Access setting “Local Archiving” in the
   Configuration Settings document of the Domino Directory server.

iNotes_WA_OOO_RunOnWeekends
   This setting was used to run the Out-of-Office agent for mail databases based on the 
   inotes5.ntf template only, and is not necessary for iNotes6.ntf or DWA7.ntf mail templates. 
   The iNotes5.ntf mail template is not an available in Domino 7.

iNotes_WA_SametimeJavaConnect
   Functionality enabled by the Domino Web Access Instant Messaging setting “Prefer Sametime 
   Java Connect for browsers” in the Configuration Settings document of the Domino Directory 
   server.

iNotes_WA_SametimeServer
   Functionality enabled by the Domino Web Access Instant Messaging setting “Set an Instant  
   Messaging server hostname for all DWA users” in the Configuration Settings document of the 
   Domino Directory server.

iNotes_WA_SametimeToken
   Functionality enabled by the Domino Web Access Instant Messaging setting “Allow secrets and 
   tokens authentication” in the Configuration Settings document of the Domino Directory server.

iNotes_WA_STLinksLocal
   Functionality enabled by the Domino Web Access Instant Messaging setting “Loading \stlinks  
   from Domino application server” in the Configuration Settings document of the Domino 
   Directory server.

iNotes_WA_OOO _RunOnWeekends
   This setting was used to run the Out-of-Office agent for mail databases based on the 
   inotes5.ntf template only, and is not necessary for iNotes6.ntf or DWA7.ntf mail templates.
   The iNotes5.ntf mail template is not an available in Domino 7.

iNotes_WA_NoLocalArchive
   Functionality now enabled by the Domino Web Access setting “Local Archiving” in the 
   Configuration Settings document of the Domino Directory server.